Inhibition of IkB Kinase and IkB Phosphorylation by 15-Deoxy- D-Prostaglandin J2 in Activated Murine Macrophages

15-Deoxy-Δ12,14-Prostaglandin J2 Protects PC12 cells from LPS-Induced Cell Death Through Nrf2 pathway in PPAR-γ Dependent Manner

Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...

Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.

Prostaglandins biosynthesis and nitric oxide production have been implicated in the process of carcinogenesis and inflammation. In this study, we investigated the effect of various flavonoids and (-)-epigallocatechin-3-gallate on the activities of inducible cyclooxygenase (COX-2) and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. Apigenin, ge...

Potentiation of Protein Kinase C Activity by 15-Deoxy- -Prostaglandin J2 Induces an Imbalance between Mitogen-Activated Protein Kinases and NF- B That Promotes Apoptosis in Macrophages

Inhibition of IFN- -Mediated Inducible Nitric Oxide Synthase Induction by the Peroxisome Proliferator-Activated Receptor Agonist, 15-Deoxy- -Prostaglandin J2, Involves Inhibition of the Upstream Janus Kinase/STAT1 Signaling Pathway

Phosphorylation of NF-kB and IkB proteins: implications in cancer and inflammation

Nuclear factor-kB (NF-kB) is a transcription factor that has crucial roles in inflammation, immunity, cell proliferation and apoptosis. Activation of NF-kB mainly occurs via IkB kinase (IKK)-mediated phosphorylation of inhibitory molecules, including IkBa. Optimal induction of NF-kB target genes also requires phosphorylation of NF-kB proteins, such as p65, within their transactivation domain by...